THE CO-REPRESSOR SMRT DELAYS DNA DAMAGE-INDUCED CASPASE ACTIVATION BY REPRESSING PRO-APOPTOTIC GENES AND MODULATING THE DYNAMICS OF CHECKPOINT KINASE 2 ACTIVATION.

Checkpoint kinase 2 (Chk2) is a major regulator of DNA damage response and can induce alternative cellular responses: cell cycle arrest and DNA repair or programmed cell death.Here, we report the identification of a new role of Chk2 in transcriptional regulation that also contributes to Liquid Soap modulating the balance between survival and apopto

Background: Autoimmune/inflammatory syndrome (ASIA) constitutes a set of related immune mediated diseases that share a common clinical picture and a history of a previous exposure to an adjuvant agent.From a clinical standpoint, patients present with none specific manifestations such as myalgia, arthralgia, chronic fatigue and dry mouth as well as

Synthetic aperture radar tomography (TomoSAR) has gained significant attention for three-dimensional (3D) imaging in urban environments.A notable limitation of traditional TomoSAR approaches is their primary focus on persistent scatterers (PSs), disregarding targets with temporal decorrelated characteristics.Temporal variations in coherence, especi

Pancreas disease caused by salmonid alphavirus in farmed Atlantic salmon (Salmo salar) leads to high mortality rates post infection and histopathological lesions in several organs.As protection against pancreas disease, Novartis Mini Pendant developed a prophylactic DNA plasmid-based vaccine to be administered to salmon as naked plasmid in a single

We used reared larvae of Gramma loreto sized 5.5 to 10.5 mm to study ontogeny of morphology and swim- ming.The larvae are slender to moderate in depth, with laterally compressed bodies, about 28 myomeres, a coiled gut that is not compact, extending to 50% to 60% of body length, an Arduino Boards inconspicuous gas bladder, head spination limited to